|
KMID : 0363320060270040895
|
|
Journal of Korean Oriental Internal Medicine
2006 Volume.27 No. 4 p.895 ~ p.904
|
|
|
Effects of Socheongryongtang-ga-seoggo and Prescription D on Airway Mucin Secretion
|
|
Kim Ho
Suh Woon-Gyo
|
|
|
Abstract
|
|
|
Objectives : In the present study, the author intended to investigate whether two oriental medical prescriptions named Socheongryongtang-ga-seoggo (SCTS) and Prescription D (P-D) significantly affect mucin release from cultured hamster tracheal surface epithelial (HTSE) cells.
Materials and Methods : Confluent HTSE cells were metabolically radiolabeled with 3H-glucosamine for 24 hrs and chased for 30 min in the presence of SCTS or P-D to assess the effect of each agent on 3H-mucin release. Possible cytotoxicities of each agent were assessed by measuring lactate dehydrogenase (LDH) release. Also, the effects of SCTS and P-D on contractility of isolated tracheal smooth muscle were investigated.
Results : SCTS did not affect mucin release from cultured HTSE cells, without cytotoxicity. However, P-D significantly increased mucin release from cultured HTSE cells. with significant cytotoxicity. SCTS inhibited Ach-induced contraction of isolated tracheal smooth muscle. P-D also inhibited Ach-induced contraction of isolated tracheal smooth muscle.
Conclusions : The author suggests that the effects of SCTS and P-D with their components should be further investigated and it is valuable to find, from oriental medical prescriptions, novel agents which might regulate mucin secretion from airway goblet cells.
|
|
|
KEYWORD
|
|
|
airway, mucus, mucin, prescription D (P-D), socheongryongtang-ga-seoggo (SCTS)
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|